The Uphoff lab

News archive


DNA repair and evolvability

May 2021

This preprint investigates the phenomenon of stress-induced mutagenesis: Cellular heterogeneity in DNA alkylation repair as a trade-off between cell survival and genetic plasticity.


Divya Choudhary

October 2020

Divya is a new DPhil student in our group and won an Indira Gandhi scholarship at Somerville College.


Chloe Cassaro

July 2020

Welcome to Chloe Cassaro who joins our group officially as a DPhil student having completed her successful DTP rotation project.


Victor Chen and Nicolas Aryanpour

July 2020

Congratulations to Victor Chen who completed an internship and his Part II Biochemistry research project, and Nicolas Aryanpour who had joined us for an ERASMUS internship as part of his Masters degree at UC Louvain! Farewell!


Postdoc vacancy

November 2020

We are looking for a microscopy enthusiast to join our team! Do you have skills in single-molecule imaging or super-resolution microscopy? Are you keen to address fundamental questions about how bacteria grow and survive? Get in touch with me by email, and apply here by 13th November 2020!!


DNA-target search

August 2020

How do DNA-binding proteins find their target sites within the dense chromosome meshwork? New preprint describes a chromosome degradation method to address this question: Transient non-specific DNA binding dominates the target search of bacterial DNA-binding proteins.


DNA damaging toxin-antitoxin system

January 2020

A story about the function of a toxin-antitoxin system in pathogenic E. coli published in Cell Reports: DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair.


Chloe Cassaro and Nicolas Aryanpour

January 2020

Welcome to DTP rotation student Chloe and internship student Nicolas from Louvain.


Article in Biophysical Journal

September 2019

Does gene expression noise jeopardize DNA damage signaling? Stochastic simulations and single-cell imaging provide some answers: A quantitative model explains single-cell dynamics of the adaptive response in Escherichia coli.


Maxence Vincent

May 2019

Welcome to Maxence Vincent who joins our group with a postdoctoral fellowship from the Human Frontiers Science Programme.


Aditya Jalin

May 2019

Aditya has won a summer vacation studentship from the Biochemical Society for a project in our lab.


Colworth Medal

April 2019

Stephan Uphoff will receive the 2020 Colworth Medal from the Biochemical Society


Poster Prize

April 2019

Valentine Lagage won a Best Poster Prize at the UK RNA Polymerase Workshop. Congratulations!


Article in J. Phys. D.

November 2018

Choosing the right label for single-molecule tracking in live bacteria: Side-by-side comparison of photoactivatable fluorescent protein and Halo tag dyes by Nehir Banaz and Jarno Makela.