DNA repair and evolvability
This preprint investigates the phenomenon of stress-induced mutagenesis: Cellular heterogeneity in DNA alkylation repair as a trade-off between cell survival and genetic plasticity.
Divya is a new DPhil student in our group and won an Indira Gandhi scholarship at Somerville College.
Welcome to Chloe Cassaro who joins our group officially as a DPhil student having completed her successful DTP rotation project.
Victor Chen and Nicolas Aryanpour
Congratulations to Victor Chen who completed an internship and his Part II Biochemistry research project, and Nicolas Aryanpour who had joined us for an ERASMUS internship as part of his Masters degree at UC Louvain! Farewell!
We are looking for a microscopy enthusiast to join our team! Do you have skills in single-molecule imaging or super-resolution microscopy? Are you keen to address fundamental questions about how bacteria grow and survive? Get in touch with me by email, and apply here by 13th November 2020!!
How do DNA-binding proteins find their target sites within the dense chromosome meshwork? New preprint describes a chromosome degradation method to address this question: Transient non-specific DNA binding dominates the target search of bacterial DNA-binding proteins.
DNA damaging toxin-antitoxin system
A story about the function of a toxin-antitoxin system in pathogenic E. coli published in Cell Reports: DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair.
Chloe Cassaro and Nicolas Aryanpour
Welcome to DTP rotation student Chloe and internship student Nicolas from Louvain.
Article in Biophysical Journal
Does gene expression noise jeopardize DNA damage signaling? Stochastic simulations and single-cell imaging provide some answers: A quantitative model explains single-cell dynamics of the adaptive response in Escherichia coli.
Welcome to Maxence Vincent who joins our group with a postdoctoral fellowship from the Human Frontiers Science Programme.
Aditya has won a summer vacation studentship from the Biochemical Society for a project in our lab.
Stephan Uphoff will receive the 2020 Colworth Medal from the Biochemical Society
Valentine Lagage won a Best Poster Prize at the UK RNA Polymerase Workshop. Congratulations!