Dr Mark Wormald - Publications and lectures

 Research Publications - Patents - Research Lectures - Training Course Lectures - Books

Research Publications
  1. Mapping space by NMR using susceptibility changes at phase boundaries.
    D.T. Edmonds, R.J.P. Williams and M.R. Wormald (1986) J. Inorg. Biochem., 28, p.381-391.
     
  2. 1H NMR chemical shift imaging of liquid-liquid interfaces.
    M.R. Wormald, R.J.P. Williams, D.T. Edmonds and J.A.B. Lohman (1987) Bruker Report, 1/1987, p.42-45.
     
  3. NMR study of acylphosphatase.
    V. Saudek, M.R. Wormald, R.J.P. Williams and G. Ramponi (1987) Biochem. Soc. Trans., 15, p.872-874.
     
  4. Theory of resonance in magnetically inhomogeneous specimens and some useful calculations.
    D.T. Edmonds and M.R. Wormald (1988) J. Magn. Reson., 77, p.223-232.
     
  5. NMR studies of calmodulin in solution: structure and dynamics in relation to function.
    J.S. Evans, B.A. Levine, R.J.P. Williams and M.R. Wormald (1988) in “Molecular aspects of cellular regulation -- volume 5”, p.57-82, ed. C. Klee and P. Cohen, pub. Elsevier.
     
  6. NMR studies of phase boundaries using magnetic susceptibility changes: relaxation rates near phase boundaries.
    M.R. Wormald, D.T. Edmonds and R.J.P. Williams (1989) Colloids and Surfaces, 36, p.179-191.
     
  7. Identification and description of b -structure in horse muscle acylphosphatase by NMR spectroscopy.
    V. Saudek, M.R. Wormald, R.J.P. Williams, J. Boyd, M. Steffani and G. Ramponi (1989) J. Mol. Biol., 207, p.405-415.
     
  8. Spectroscopic properties of the FUR (ferric uptake regulatory) protein of Escherichia coli K-12.
    R.J.P. Williams, M.R. Wormald, R.C. Heider and J.B. Neilands (1989) UCLA Symp. Mol. Cell Biol., 98, p.189-196.
     
  9. Solution NMR studies of colicin E1 C-terminal thermolytic peptide: structural comparison with colicin A and effects of pH changes.
    M.R. Wormald, A.R. Merrill, W.A. Cramer and R.J.P. Williams (1990) Eur. J. Biochem., 191, p.155-161.
     
  10. Structure and function of X-Pro dipeptide repeats in the TonB protein of Salmonella typhimurium and Escherichia coli.
    S. Brewer, M. Tolley, I.P. Trayer, G.C. Barr, C.J. Dorman, K. Hannavy, C.F. Higgins, J.S. Evans, B.A. Levine and M.R. Wormald (1990) J. Mol. Biol., 216, p.883-895.
     
  11. Full simulation of ROESY, including the Hartmann-Hahn effects.
    R. Bazzo, C.J. Edge, M.R. Wormald, T.W. Rademacher and R.A. Dwek (1990) Chem. Phys. Lett., 174, p.313-319.
     
  12. Some structural features of ferric uptake regulatory protein.
    T. Saito, M.R. Wormald and R.J.P. Williams (1990) Eur. J. Biochem., 197, p.29-38.
     
  13. The conformational effects of N-glycosylation on the tailpiece from serum IgM.
    M.R. Wormald, E.W. Wooten, R. Bazzo, C.J. Edge, A. Feinstein, T.W. Rademacher and R.A. Dwek (1991) Eur. J. Biochem., 198, p.131-139.
     
  14. Following the spatial distribution of a solid dissolving at an interface by high resolution NMR spectroscopy.
    R.J.P. Williams and M.R. Wormald (1991) J. Chem. Soc., Faraday Trans., 87, p.1585-1589.
     
  15. Characterisation of oligosaccharides from Drosophila melanogaster glycoproteins.
    P.J. Williams, M.R. Wormald, R.A. Dwek, T.W. Rademacher, G.F. Parker and D.R. Roberts (1991) Biochem. Biophys. Acta, 1075, p.146-153.
     
  16. Changes in IgG glycoform levels are associated with remission of arthritis during pregnancy.
    G.A.W. Rook, J. Steele, R. Brealey, A. Whyte, D. Isenberg, N. Sumar, J.L. Nelson, K.B. Bodman, A. Young, I.M. Roitt, P. Williams, I. Scragg, C.J. Edge, P.D. Arkwright, D. Ashford, M.R. Wormald, P. Rudd, C.W.G. Redman, R.A. Dwek and T.W. Rademacher (1991) J. Autoimmunity, 4, p.779-794.
     
  17. The solution conformation of LeX.
    M.R. Wormald, C.J. Edge and R.A. Dwek (1991) Biochem. Biophys. Res. Comm., 180, p.1214-1221.
     
  18. New methods for measurement of long-range proton-carbon coupling constants in oligosaccharides.
    D. Uhrin, A. Melee, J. Boyd, M.R. Wormald and R.A. Dwek (1992) J. Magn. Reson., 97, p.411-418.
     
  19. Fast sequencing of oligosaccharides: the reagent-array analysis method.
    C.J. Edge, T.W. Rademacher, M.R. Wormald, R.B. Parekh, T. Butters, D. Wing and R.A. Dwek (1992) Proc. Natl. Acad. Sci. USA, 89, p.6338-6342.
     
  20. Product Note - Fast sequencing of oligosaccharides using arrays of enzymes.
    C.J. Edge, R.B. Parekh, T.W. Rademacher, M.R. Wormald and R.A. Dwek (1992) Nature, 358, p.693-694.
     
  21. The use of hydrazine to release in intact and unreduced form both N- and O-linked oligosaccharides from glycoproteins.
    T. Patel, J. Bruce, A. Merry, C. Bigge, M.R. Wormald, A. Jacques and R.B. Parekh (1993) Biochemistry, 32, p.679-693.
     
  22. The conformational effects of N-linked glycosylation.
    C.J. Edge, H.C. Joao, I.G. Scragg, R.J. Woods and M.R. Wormald (1993) Biochem. Soc. Trans., 21, p.452-455.
     
  23. Analysis of glycoprotein-associated oligosaccharides.
    R.A. Dwek, C.J. Edge, D.J. Harvey, M.R. Wormald and R.B. Parekh (1993) Ann. Rev. Biochem., 62, p.65-100.
     
  24. The systematic use of negative nuclear Overhauser constraints in the determination of oligosaccharide conformations: application to sialyl-Lewis X.
    M.R. Wormald and C.J. Edge (1993) Carbohydr. Res., 246, p.337-344.
     
  25. Synthesis of 1,5-dideoxy-3-O-(a-D-mannopyranosyl)-1,5-imino-D-mannitol and 1,5-dideoxy-3-O-(a-D-glucopyranosyl)-1,5-imino-D-mannitol: Powerful inhibitors of an endomannosidase.
    H. Ardron, T.D. Butters, F.M. Platt, M.R. Wormald, R.A. Dwek, G.W.J. Fleet and G.S. Jacob (1993) Tetrahedron Asymmetry, 4, p.2011-2024.
     
  26. GLYCAM_93: A generalised parameter set for glycoproteins and oligosaccharides. Application to the structure and dynamics of a disaccharide related to oligomannose.
    R.J. Woods, C.J. Edge, M.R. Wormald and R.A. Dwek (1994) in “Complex Carbohydrates in Drug Research”, Alfred Benzon Symposium 36, p.15-26, ed. K. Bock and H. Clausen, pub. Munksgaard, Copenhagen.
     
  27. Binding of sugar ligands to Ca2+-dependent animal lectins : 1. Analysis of mannose binding by site-directed mutagenesis and NMR.
    S.T. Iobst, M.R. Wormald, W.I. Weis, R.A. Dwek and K. Drickamer (1994) J. Biol. Chem., 269, p.15505-15511.
     
  28. Casuarine: A very highly oxygenated pyrrolizidine alkaloid.
    R.J. Nash, P.I. Thomas, R.D. Waigh, G.W.J. Fleet, M.R. Wormald, P.M. de Q. Lilley and D.J. Watkin (1994) Tetrahedron Lett., 35, p.7849-7852.
     
  29. Tri- and tetra-peptides incorporating an a -amino acid at the anomeric position of mannofuranose.
    J.C. Estevez, R. Estevez, H. Ardron, M.R. Wormald, D. Brown and G.W.J. Fleet (1994) Tetrahedron Lett., 35, p.8885-8888.
     
  30. Spirocyclic peptides at the anomeric position of mannofuranose.
    J.C. Estevez, H. Ardron, M.R. Wormald, D. Brown and G.W.J. Fleet (1994) Tetrahedron Lett., 35, p.8889-8890.
     
  31. The potential of trees as sources of new drugs and pesticides.
    R.J. Nash, A.C. Longland and M.R. Wormald (1994) in “Agroforestry Systems for Degraded Lands, Vol 2”, p.899-910, ed. P. Singh, P.S. Pathak and M.M. Roy, pub. Oxford & IBH, New Delhi.
     
  32. Potent inhibition of glycogen phosphorylase by a spirohydantoin of glucopyranose: first pyranose analogues of hydantocidin.
    C.J.F. Bichard, E.P. Mitchell, M.R. Wormald, K.A. Watson, L.N. Johnson, S.E. Zographos, D.D. Koutra, N.G. Oikonomakos and G.W.J. Fleet (1995) Tetrahedron Lett., 36, p.2145-2148.
     
  33. The effects of variable glycosylation on the functional activities of ribonuclease, plasminogen and tissue plasminogen activator.
    P.M. Rudd, R.J. Woods, M.R. Wormald, G. Opdenakker, A.K. Downing, I.D. Campbell and R.A. Dwek (1995) Biochem. Biophys. Acta, 1248, p.1-10.
     
  34. Cells regulate the activities of cytokines by glycosylation.
    G. Opdenakker, P.M. Rudd, M.R. Wormald, R.A. Dwek and J. van Damme (1995) FASEB J., 9, p.453-457.
     
  35. Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein.
    R. Malhotra, M.R. Wormald, P.M. Rudd, P.B. Fischer, R.A. Dwek and R.B. Sim (1995) Nature Medicine, 1, p.237-243.
     
  36. Glycobiology: The function of sugar in the IgG molecule.
    R.A. Dwek, A.C. Lellouch and M.R. Wormald (1995) J. Anat., 187, p.279-292.
     
  37. Spirodiketopiperazines at the anomeric position of mannopyranose: Novel N-linked glycopeptides incorporating an a -amino acid at the anomeric position of mannopyranose.
    J.C. Estevez, D.D. Long, M.R. Wormald, R.A. Dwek and G.W.J. Fleet (1995) Tetrahedron Lett., 36, p.8287-8290.
     
  38. Lectin-carbohydrate interactions in disease. T-cell recognition of IgA and IgD; Mannose binding protein recognition of IgG0.
    P.M. Rudd, F. Fortune, T. Lehner, R. Parekh, T. Patel, M.R. Wormald, R. Malhotra, R. Sim and R.A. Dwek (1995) Adv. Exp. Med. Biol., 376, p.147-152.
     
  39. Selective placental transport of maternal IgG to the fetus.
    P.J. Williams, P.D. Arkwright, P.M. Rudd, I.G. Scragg, C.J. Edge, M.R. Wormald and T.W. Rademacher (1995) Placenta, 16, p.749-756.
     
  40. A galactopyranose analogue of hydantocidin.
    T. Brandstetter, M.R. Wormald, R.A. Dwek, T.D. Butters, F.M. Platt, K.E. Tsitsanou, S.E. Zographos, N.G. Oikonomakos and G.W.J. Fleet (1996) Tetrahedron Asymmetry, 7, p.157-170.
     
  41. Mimics of L-rhamnose: Analogues of rhamnopyranose containing a constituent a -amino acid at the anomeric position. A pyranose analogue of hydantocidin.
    J.C. Estevez, M.D. Smith, M.R. Wormald, G.S. Besra, P.J. Brennan, R.J. Nash and G.W.J. Fleet (1996) Tetrahedron Asymmetry, 7, p.391-394.
     
  42. Effect of serine O-glycosylation on cis-trans proline isomerization.
    Y.L. Pao, M.R. Wormald, R.A. Dwek and A.C. Lellouch (1996) Biochem. Biophys. Res. Comm., 219, p.157-162.
     
  43. The isolation from Nicandra physalodes and identification of the 3-O-b -D-glucopyranoside of 1a ,2b ,3a ,6a -tetrahydroxy-nor-tropane (calystegine B1).
    R.C. Griffiths, A.A. Watson, H. Kizu, N. Asano, H.J. Sharp, M.G. Jones, M.R. Wormald, G.W.J. Fleet and R.J. Nash (1996) Tetrahedron Lett., 37, p.3207-3208.
     
  44. Casuarine-6-a -D-glucoside from Casuarina equisetifolia and Eugenia jambolana.
    M.R. Wormald, R.J. Nash, A.A. Watson, B.K. Bhadoria, R. Langford, M. Sims and G.W.J. Fleet (1996) Carbohydrate Lett., 2, 169-174.
     
  45. Unusual uniformity of the N-linked oligosaccharides of HLA-A, B and C glycoproteins.
    L.D. Barber, T.P. Patel, L. Percival, J.E. Gumperz, L.L. Lanier, J.H. Phillips, J.C. Bigge, M.R. Wormald, R.B. Parekh and P. Parham (1996) J. Immunol., 156, p.3275-3284.
     
  46. Variations in oligosaccharide-protein interactions in IgG determine the site-specific glycosylation profiles and modulate the dynamic motion of the Fc oligosaccharides.
    M.R. Wormald, P.M. Rudd, D.J. Harvey, S.-C. Chang, I.G. Scragg and R.A. Dwek (1997) Biochemistry, 36, p.1370-1380.
     
  47. The glycosylation of the complement regulatory protein, CD59.
    P.M. Rudd, B.P. Morgan, M.R. Wormald, D.J. Harvey, C.W. van den Berg, S.J. Davis, M.A.J. Ferguson and R.A. Dwek (1997) J. Biol. Chem., 272, p.7229-7244.
     
  48. Novel biologically active alkaloids from British plants.
    R.J. Nash, A.A. Watson, A.L. Winters, G.W.J. Fleet, M.R. Wormald, S. Dealler, E. Lees, N. Asano and H. Kizu (1997) in “Phytochemical Diversity”, p.106-114, ed. S. Wrigley, M. Hayes, R. Thomas and E. Chrystal, pub. Royal Society of Chemistry, London.
     
  49. The solution NMR structure of glucosylated N-glycans involved in the early stages of glycoprotein biosynthesis and folding.
    A.J. Petrescu, T.D. Butters, G. Reinkensmeier, S. Petrescu, F.M. Platt, R.A. Dwek and M.R. Wormald (1997) EMBO J., 16, p.4302-4310.
     
  50. Roles for glycosylation in the anti-inflammatory molecule CD59.
    P.M. Rudd, B.P. Morgan,  M.R. Wormald, D.J. Harvey, C.W. van den Berg, S.J. Davis, M.A.J. Ferguson and R.A. Dwek (1997) Biochem. Soc. Trans., 25, p.1177-1184.
     
  51. Glycosidase-inhibiting pyrrolidine alkaloids from Hyacinthoides non-scripta.
    A.A. Watson, R.J. Nash, M.R. Wormald, D.J. Harvey, S. Dealler, E. Lees, N. Asano, H. Kizu, A. Kato, R.C. Griffiths, A.J. Cairns and G.W.J. Fleet (1997) Phytochemistry, 46, p.255-259.
     
  52. The glycosylation and structure of human serum IgA1, Fab and Fc regions and the role of N-glycosylation on Fca receptor interactions.
    T.S. Mattu, R.J. Pleass, A.C. Willis, M. Killian, M.R. Wormald, A.C. Lellouch, P.M. Rudd, J.M. Woof  and R.A. Dwek (1998) J. Biol. Chem., 273, p.2260-2272.
     
  53. The glycosylation of the complement regulatory protein, human erythrocyte CD59.
    P.M. Rudd, B.P. Morgan, M.R. Wormald, D.J. Harvey, C.W. van den Berg, S.J. Davis, M.A.J. Ferguson and R.A. Dwek (1998) Adv. Exp. Med. Biol., 435, p.153-162.
     
  54. Glycosidase inhibitors in British plants as causes of livestock disorders.
    R.J. Nash, A.A. Watson, A.L. Winters, G.W.J. Fleet,  M.R. Wormald, S. Dealler, E. Lees, N. Asano and R.J. Molyneux (1998) in “Toxic plants and other natural toxicants”, p.276-284, ed. T. Garland and A.C. Barr, pub. CAB International.
     
  55. Spirodiketopiperazines of mannofuranose: carbopeptoid a-amino acid esters at the anomeric position of mannofuranose.
    J.C. Estevez, J.W. Burton, R.J. Estevez, H. Ardron, M.R. Wormald, R.A. Dwek, D. Brown and G.W.J. Fleet (1998) Tetrahedron Asymmetry, 9, p.2137-2154.
     
  56. Configurational and conformational analysis of highly oxygenated pyrrolizidines: Definitive identification of some naturally occurring 7a-epi-alexines.
    M.R. Wormald, R.J. Nash, P. Hrnciar, J.D. White, R.J. Molyneux and G.W.J. Fleet (1998) Tetrahedron Asymmetry, 9, p.2549-2558.
     
  57. The high degree of internal flexibility observed for an oligomannose oligosaccharide is not reproduced in the overall topology of the molecule.
    R.J. Woods, A. Pathiaseril, M.R. Wormald, C.J. Edge and R.A. Dwek (1998) Eur. J. Biochem., 258, p.372-386.
     
  58. Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity.
    A. Glithero, J. Tormo, J.S. Haurum, G. Arsequell, G. Valencia, J. Edwards, S. Springer, A. Townsend, Y.-L. Pao, M.R. Wormald, R.A. Dwek, E.Y. Jones and T. Elliott (1999) Immunity, 10, p.63-74.
     
  59. A statistical analysis of N- and O-glycan linkage conformations from crystallographic data.
    A.J. Petrescu, S.M. Petrescu, R.A. Dwek and M.R. Wormald (1999) Glycobiology, 9, p.343-352.
     
  60. Oligosaccharide analysis and molecular modeling of soluble forms of glycoproteins belonging to the Ly-6, scavenger receptor and immunoglobulin superfamilies expressed in Chinese hamster ovary cells.
    P.M. Rudd, M.R. Wormald, D.J. Harvey, M. Devashayem, M.S.B. McAlister, M.H. Brown, S.J. Davis, A.N. Barclay and R.A. Dwek (1999) Glycobiology, 9, p.443-458.
     
  61. Minireview: Glycosylation and the immune system.
    P.M. Rudd, M.R. Wormald and R.A. Dwek (1999) Trends in Glycoscience and Glycotechnology, 11, p.1-21.
     
  62. Glycoproteins: glycan presentation and protein-fold stability.
    M.R. Wormald and R.A. Dwek (1999) Structure, 7, p.R155-R160.
     
  63. Polyhydroxylated pyrrolidine and pyrrolizidine alkaloids from Hyacinthoides non-scripta and Scilla campanulata.
    A. Kato, I. Adachi, M. Miyauchi, K. Ikeda, T. Komae, H. Kizu, Y. Kameda, A.A. Watson, R.J. Nash, M.R. Wormald, G.W.J. Fleet and N. Asano (1999) Carbohydr. Res., 316, p.95-103.
     
  64. Tyrosinase folding and copper loading in vivo: a crucial role for calnexin and alpha-glucosidase II.
    N. Branza-Nichita, A.J. Petrescu, R.A. Dwek, M.R. Wormald, F.M. Platt and S.M. Petrescu (1999) Biochem. Biophys. Res. Comm., 261, p.720-725.
     
  65. The glycosylation of natural human neutrophil gelatinase B and neutrophil gelatinase B-associated lipocalin.
    P.M. Rudd, T.S. Mattu, S. Masure, T. Bratt, P.E. van den Steen, M.R. Wormald, B. Küster, D.J. Harvey, N. Borregaard, J. van Damme, R.A. Dwek and G. Opdenakker (1999) Biochemistry, 38, p.13937-13950.
     
  66. Roles for glycosylation of cell surface receptors involved in cellular immune recognition.
    P.M. Rudd, M.R. Wormald, R.L. Stanfield, M. Huang, N. Mattson, J.A. Speir, J.A. DiGennaro, J.S. Fetrow, R.A. Dwek and I.A. Wilson (1999) J. Mol. Biol., 293, p.351-366.
     
  67. Glycosylation differences between the normal and pathogenic prion protein isoforms.
    P.M. Rudd, T. Endo, C. Colominas, D. Groth, S.F. Wheeler, D.J. Harvey, M.R. Wormald, H. Serban, S.B. Prusiner, A. Kobata and R.A. Dwek (1999) Proc. Natl. Acad. Sci. USA, 96, p.13044-13049.
     
  68. Exploring functions for glycosylation in host defense using novel oligosaccharide sequencing technology.
    P.M. Rudd, M.R. Wormald and R.A. Dwek (1999) in “Proteome and protein analysis”, p.321-339, ed. R.M. Kamp, D. Kyriakidis and T. Choli-Papadopoulou (Springer-Verlag).
     
  69. Hybrid and complex glycans are linked to the conserved N-glycosylation site of the third eight-cysteine domain of LTBP-1 in insect cells.
    P.M. Rudd, A.K. Downing, M. Cadene, D.J. Harvey, M.R. Wormald, I. Weir, R.A. Dwek, D.B. Rifkin and P.-E. Gleizes (2000) Biochemistry, 39, p.1596-1603.
     
  70. Molecular requirements of imino sugars for the selective control of N-linked glycoslyation and glycosphingolipid biosynthesis.
    T.D. Butters, L.A.G.M. van den Broek, G.W.J. Fleet, T.M. Krulle, M.R. Wormald, R.A. Dwek and F.M. Platt (2000) Tetrahedron Asymmetry, 11, p.113-124.
     
  71. Mutations at critical N-glycosylation sites reduce tyrosinase activity by altering folding and quality control.
    N. Branza-Nichita, G. Negroiu, A.J. Petrescu, E.F. Garman, F.M. Platt, M.R. Wormald, R.A. Dwek and S.M. Petrescu (2000) J. Biol. Chem., 275, 8169-8175.
     
  72. Minireview: O-link glycosylation in focus.
    P.E. van den Steen, P.M. Rudd, M.R. Wormald, R.A. Dwek and G. Opdenakker (2000) Trends in Glycoscience and Glycotechnology, 12, 35-49.
     
  73. The O-glycan analysis of natural neutrophil gelatinase B using a novel strategy combining normal phase HPLC and on-line tandem mass spectrometty: implications for the domain organisation of the enzyme.
    T.S. Mattu, L. Royle, J. Langridge, M.R. Wormald, P.E. Van den Steen, J. Van Damme, G. Opdenakker, D.J. Harvey, R.A. Dwek and P.M. Rudd (2000) Biochemistry, 39, 15965-15704.
     
  74. Fluorescence labelling of carbohydrates with 2-aminobenzamide (2AB).
    R.R. France, I. Cumpstey, T.D. Butters, A.J. Fairbanks and M.R. Wormald (2000) Tetrahedron Asymmetry, 11, 4985-4994.
     
  75. Rapid, sensitive HPLC-based sequencing strategies of N- and O-linked oligosaccharides attached to 5-20 micro-grams of glycoproteins.
    P.M. Rudd, T.S. Mattu, M.R. Wormald, D.J. Harvey and R.A. Dwek (2000) in "Pharmeuropa, Biologicals Beyond 2000", pp.103-118 (European Directorate for the Quality of Medicines).
     
  76. Prion glycoprotein: Structure, dynamics and roles for the sugars.
    P.M. Rudd, M.R. Wormald, D. Wing, S.B. Prusiner and R.A. Dwek (2001) Biochemistry, 40, 3759-3766.
     
  77. Carbopeptoids: Peptides and diketopiperazines incorporating the anomeric centre of mannopyranose.
    D.D. Long, R.J. Tennant-Eyles, J.C. Estevez, M.R. Wormald, R.A. Dwek, M.D. Smith and G.W.J. Fleet (2001) J. Chem. Soc. Perkin Trans I, 807-813.
     
  78. A family of novel, acidic N-glycans in Bowes melanoma tissue plasminogen activator have 2/HNK-1-bearing antennae, many with sulfation of the fucosylated chitobiose core.

    79. S. Zamze, D.R. Wing, M.R. Wormald, A.P. Hunter, R.A. Dwek and D.J. Harvey (2001) Eur. J. Biochem., 268, 4063-4078.
     
  79. Antibodies inhibit prion propagation and clear cell cultures of prion infectivity.
    D. Peretz, R.A. Williamson, K. Kaneko, J. Vergara, E. Leclerc, G. Schmitt-Uims, I.R. Mehlhorn, G. Legname, M.R. Wormald, P.M. Rudd, R.A. Dwek, D.R. Burton and S.B. Prusiner (2001) Nature, 412, 739-743.
     
  80. Matrix remodelling enzymes, the protease cascade and glycosylation.
    P.E. Van den Steen, G. Opdenakker, M.R. Wormald, R.A. Dwek and P.M. Rudd (2001) Biochim. Biophys. Acta, 1528, 61-73.
     
  81. "Internal residue loss": Rearrangements occurring during the fragmentation of carbohydrates derivatized at the reducing terminus.
    D.J. Harvey, T.S. Mattu, M.R. Wormald, L. Royle, R.A. Dwek and P.M. Rudd (2002) Anal. Chem., 74, 734-740.
     
  82. Conformational studies of oligosaccharides and glycopeptides: Complementarity of NMR, X-ray crystallography, and molecular modelling.
    M.R. Wormald, A.J. Petrescu, Y.-L. Pao, A. Glithero, T. Elliott and R.A. Dwek (2002) Chemical Reviews, 102, 371-386.
     
  83. The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of a1-2 mannose residues on the outer face of gp120.
    C.N. Scanlan, R. Pantophlet, M.R. Wormald, E.O. Saphire, R. Stanfield, I.A. Wilson, H. Katinger, R.A. Dwek, P.M. Rudd and D.R. Burton (2002) J. Virology, 76, 7306-7321.
     
  84. Preparation, biochemical characterization and biological properties of radiolabelled N-alkylated deoxynojirimycins.
    H.R. Mellor, J. Nolan, L. Pickering, M.R. Wormald, F.M. Platt, R.A. Dwek, G.W.J. Fleet and T.D. Butters (2002), Biochem. J., 366, p225-233.
     
  85. Editorial Overview - Hot roles for glycosylation : signal transduction, control of cell development and differentiation, and innate immunity.
    M.R. Wormald and N. Sharon (2002) Curr. Op. Struc. Biol., 12, p.567-568.
     
  86. Glycosylation and prion protein.
    P.M. Rudd, A.H. Merry, M.R. Wormald and R.A. Dwek (2002) Curr. Op. Struc. Biol., 12, p.578-586.
     
  87. Total synthesis of the Glc3Man N-glycan tetrasaccharide.
    S.C. Ennis, I.C. Cumpstey, A.J. Fairbanks, T.D. Butters, M. Mackeen and M.R. Wormald (2002), Tetrahedron, 58, p.9403-9411.
     
  88. Australine and related alkaloids: easy structural confirmation by 13C NMR spectral data and biological activities.
    A. Kato, E. Kano, I. Adachi, R.J. Molyneux, A.A. Watson, R.J. Nash, G.W.J. Fleet, M.R. Wormald, H. Kizu, K. Ikeda and N. Asano (2003) Tetrahedron Asymmetry, 14, p.325-331.
     
  89. Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems.
    L. Royle, A. Roos, D.J. Harvey, M.R. Wormald, D.J. van Gijlswijk-Janssen, E-R.M. Redwan, I.A. Wilson, M.R. Daha, R.A. Dwek and P.M. Rudd (2003) J. Biol. Chem., 278, p.20140-20153.
     
  90. Antibody domain exchange is an immunological solution to carbohydrate cluster recognition.
    D.A. Calarese, C.N. Scanlan, M.B. Zwick, S. Deechongkit, Y. Mimura, R. Kunert, P. Zhu, M.R. Wormald, R.L. Stanfield, K.H. Roux, J.W. Kelly, P.M. Rudd, R.A. Dwek, H. Katinger, D.R. Burton and I.A. Wilson (2003) Science, 300, p.2065-2071.
     
  91. O-glycan sialylation and the structure of the stalk-like region of the T cell coreceptor CD8.
    A. Merry, R.J.C. Gilbert, D.A. Shore, L. Royle, O. Miroshnychenko, M. Vuong, M.R. Wormald, D.J. Harvey, R.A. Dwek, B.J. Classon, P.M. Rudd and S.J. Davis (2003) J. Biol. Chem., 278, p.27119-27128.
     
  92. Synthesis of fluorescence-labelled disaccharide substrates of glucosidase II.
    I. Cumpstey, T.D. Butters, R.J. Tennant-Eyles, A.J. Fairbanks, R.R. France and M.R. Wormald (2003) Carbohydr. Res., 338, p.1937-1949.
     
  93. The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12.
    C.N. Scanlan, R. Pantophlet, M.R. Wormald, E.O. Saphire, D. Calarese, R. Stanfield, I.A. Wilson, H. Katinger, R.A. Dwek, D.R. Burton and P.M. Rudd (2003) Adv. Exp. Med. Biol., 535, p.205-218.
     
  94. Statistical analysis of the protein environment of N-glycosylation sites: implications for occupancy, structure and folding.
    A.-J. Petrescu, A.-L. Milac, S.M. Petrescu, R.A. Dwek and M.R. Wormald (2004) Glycobiology, 14, p.103-114.
     
  95. Complement regulation at the molecular level: the structure of decay-accelerating factor.
    P. Lukacik, P. Roversi, J. White, D. Esser, G.P. Smith, J. Billington, P.A. Williams, P.M. Rudd, M.R. Wormald, D.J. Harvey, M.D.M. Crispin, C.M. Radcliffe, R.A. Dwek, D.J. Evans, B.P. Morgan, R.A.G. Smith and S.M. Lea (2004) Proc. Natl. Acad. Sci. USA, 101, p.1279-1284.
     
  96. maternally expressed gene1 is a novel maize endosperm transfer cell-specific gene with a maternal parent-of-origin pattern of expression.
    J.F. Gutierrez-Marcos, L.M. Costa, C. Biderre-Petit, B. Khbaya, D. O'Sullivan, M.R. Wormald, P. Perez and H.G. Dickinson (2004) Plant Cell, 16, p.1288-1301.
     
  97. Controlled glycosylation of therapeutic antibodies in plants.
    Y. Tekoah, K. Ko, H. Koprowski, D.J. Harvey, M.R. Wormald, R.A. Dwek and P.M. Rudd (2004) Archives of Biochemistry and Biophysics, 426, p.266-278.
     
  98. Looking-glass inhibitors: L-DMDP, a more potent and specific inhibitor of -glucosidases than the enantiomeric natural product DMDP.
    C.-Y. Yu, N. Asano, K. Ikeda, M.-X. Wang, T.D. Butters, M.R. Wormald, R.A. Dwek, A.L. Winters, R.J. Nash and G.W. J. Fleet (2004) Chem. Commun., 17, p.1936-1937.
     
  99. Sugar-mediated receptor-ligand interactions in the immune system.
    P.M. Rudd, M.R. Wormald and R.A. Dwek (2004) Trends in Biotechnology, 22, p.524-530.
     
  100. Editorial Overview - Progress in non-mammalian glycosylation, glycosyltransferases, invertebrate lectins and carbohydrate-carbohydrate interactions.
    M.R. Wormald and N. Sharon (2004) Curr. Op. Struc. Biol., 14, p.591-592.
     
  101. The glycosylation of human serum IgD and IgE and the accessibility of identified oligomannose structures for interaction with mannan binding lectin.
    J.N. Arnold, C.M. Radcliffe, M.R. Wormald, L. Royle, D.J. Harvey, M.D.M. Crispin, R.A. Dwek, R.B. Sim and P.M. Rudd (2004) J. Immunol., 173, p.6831-6840.
     
  102. 2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-ribitol.
    C.C. Harding, D.J. Watkin, J.S.S. Rountree, T.D. Butters, M.R. Wormald, R.A. Dwek, and G.W.J. Fleet (2005) Acta Cryst., E61, p.o930-o932.
     
  103. Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease.
    C. Boucheron, V. Desvergnes, P. Compain, O.R. Martin, A. Lavi, M. Mackeen, M.R. Wormald, R.A. Dwek and T.D. Butters (2005) Tetrahedron Asymmetry, 16, p.1747-1756.
     
  104. 2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-arabinitol 0.33-hydrate.
    C.C. Harding, J.S.S. Rountree, D.J. Watkin, A.R. Cowley, T.D. Butters, M.R. Wormald, R.A. Dwek and G.W.J. Fleet (2005) Acta Cryst., E61, p.o1683-o1685.
     
  105. 1,2:3,4-Di-O-isopropylidene-a-D-tagatofuranose.
    D.J. Watkin, A.F.G. Glawar, R. Soengas, U.P. Skytte, M.R. Wormald, R.A. Dwek and G.W.J. Fleet (2005) Acta Cryst., E61, p.o2891-o2893.
     
  106. Human serum IgM glycosylation: identification of glycoforms which can bind to mannan binding lectin.
    J.N. Arnold, M.R. Wormald, D.M. Suter, C.M. Radcliffe, D.J. Harvey, R.A. Dwek, P.M. Rudd and R.B. Sim (2005) J. Biol. Chem., 280, p.29080-29087.
     
  107. 1,2:3,4-Di-O-isopropylidene-b-D-psicofuranose.
    D.J. Watkin, A.F.G. Glawar, R. Soengas, K. Izumori, M.R. Wormald, R.A. Dwek and G.W.J. Fleet (2005) Acta Cryst., E61, p.o2949-o2951.
     
  108. Afamin is a novel human vitamin E-binding glycoprotein: characterization and in vitro expression.
    L. Jerkovic, A.F. Voegele, S. Chwatal, F. Kronenberg, C.M. Radcliffe, M.R. Wormald, E.M. Lobentanz, B. Ezeh, P. Eller, N. Dejori, B. Dieplinger, F. Lottspeich, W. Sattler, M. Uhr, K. Mechtler, R.A. Dwek, P.M. Rudd, G. Baier and H. Dieplinger (2005) J. Proteome Res., 4, p.889-899.
     
  109. Glycosylation influences the lectin activities of the macrophage mannose receptor.
    Y. Su, T. Bakker, J. Harris, C. Tsang, G.D. Brown, M.R. Wormald, S. Gordon, R.A. Dwek, P.M. Rudd and L. Martinez-Pomares (2005) J. Biol. Chem., 280, p.32811-32820.
     
  110. Differential glycosylation of gelatinase B from neutrophils and breast cancer cells.
    S.A. Fry, P.E. Van den Steen, L. Royle, M.R. Wormald, A.J. Leathern, G. Opdenakker, P.M. Rudd and R.A. Dwek (2005) Adv. Exp. Med. Biol., 564, p.103-112.
     
  111. 3,7,7a-Tri-epi-casuarine pentaacetate.
    F. Punzo, D.J. Watkin, J. Van Ameijde, G. Horne, G.W.J. Fleet, M.R. Wormald and R.J. Nash (2006) Acta Cryst., E62, p.o928-o930.
     
  112. Variable region heavy chain glycosylation determines the anticoagulant activity of a factor VIII antibody.
    M. Jacquemin, C.M. Radcliffe, R. Lavend'homme, M.R. Wormald, L. VanderElst, G. Wallays, J. Dewaele, D. Collen, J. Vermylen, R.A. Dwek, J.-M. Saint-Remy, P.M. Rudd and M. Dewerchin (2006) J. Thromb. Haemost., 4, p.1047-1055.
     
  113. Remnant epitopes, autoimmunity and glycosylation.
    G. Opdenakker, C. Dillen, P. Fiten, E. Martens, I. Van Aelst, P.E. Van den Steen, I. Nelissen, S. Starckx, F.J. Descamps, J. Hu, H. Piccard, J. Van Damme, M.R. Wormald, P.M. Rudd and R.A. Dwek (2006) Biochem. Biophys. Acta, 1760, p.610-615.
     
  114. The importance of including local correlation times in the calculation of inter-proton distances from NMR measurements: ignoring local correlation times leads to significant errors in the conformational analysis of the Glc 1-2Glc linkage by NMR spectroscopy.
    M. Mackeen, A. Almond, I. Cumpstey, S.C. Enis, E. Kupce, T.D. Butters, A.J. Fairbanks, R.A. Dwek and M.R. Wormald (2006) Org. Biomol. Chem., 4, p.2241-2246.
     
  115. Sialylation of urinary prothrombin fragment 1 is implicated as a contributory factor in the risk of calcium oxalate kidney stone formation.
    D. Webber, C.M. Radcliffe, L. Royle, G. Tobiasen, A.H. Merry, A.L. Rodgers, E.D. Sturrock, M.R. Wormald, D.J. Harvey, R.A. Dwek and P.M. Rudd (2006) FEBS Letters, 273, p.3024-3037.
     
  116. The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bio-availability via inhibition and binding to cargo receptors.
    P.E. Van den Steen, I. Van Aelst, V. Hvidberg, H. Piccard, P. Fiten, C. Jacobsen, S.K. Moestrup, S. Fry, L. Royle, M.R. Wormald, R. Wallis, P.M. Rudd, R.A. Dwek and G. Opdenakker (2006) J. Biol. Chem., 281, p.18626-18637.
     
  117. Chromophore structure in the photocycle of the cyanobacterial phytochrome Cph1.
    J.J. van Thor, M. Mackeen, I. Kuprov, R.A. Dwek and M.R. Wormald (2006) Biophys. J., 91, p.1811-1822.
     
  118. Sugar amino acids at the anomeric position of carbohydrates: synthesis of spirocyclic amino acids of 6-deoxy-L-lyxofuranose.
    Y. Bleriot, M.I. Simone, M.R. Wormald, R.A. Dwek, D.J. Watkin and G.W. J. Fleet (2006) Tetrahedron Asymmetry, 17, p.2276-2286.
     
  119. Structural aspects of glycomes with a focus on N-glycosylation and glycoprotein folding.
    A.J. Petrescu, M.R. Wormald and R.A. Dwek (2006) Curr. Op. Struc. Biol., 16, p.600-607.
     
  120. Isolation, synthesis and glycosidase inhibition profile of 3-epi-casuarine.
    J. Van Ameijde, G. Horne, M.R. Wormald, R.A. Dwek, R.J. Nash, P. Wyn Jones, E.L. Evinson and G.W. J. Fleet (2006) Tetrahedron Assymetry, 17, p.2702-2712.
     
  121. Structural comparison of differentially glycosylated forms of acid- -glucosidase, the defective enzyme in Gaucher disease.
    B. Brumshtein, M.R. Wormald, I. Silman, A.H. Futerman and J.L. Sussman (2006) Acta Cryst., D62, p.1458-1465.
     
  122. Cancer associated glycoforms of gelatinase B exhibit decreased binding to galectin-3.
    S.A. Fry, P.E. Van den Steen, L. Royle, M.R. Wormald, A.J. Leathem, G. Opdenakker, J.M. McDonnell, R.A. Dwek and P.M. Rudd (2006) Biochemistry, 45, p.15249-15258.
     
  123. Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B cell receptor.
    C.M. Radcliffe, J.N. Arnold, D.M. Suter, M.R. Wormald, D.J. Harvey, L. Royle, Y. Mimura, Y. Kimura, R.B. Sim, S. Inogès, M. Rodriguez-Calvillo, N. Zabalegui, A. López-Díaz de Cerio, K.N. Potter, C.I. Mockridge, R.A. Dwek, M. Bendandi, P.M. Rudd and F.K. Stevenson (2007) J. Biol. Chem., 282, p.7405-7415.
     
  124. The impact of glycosylation on the biological function and structure of human immunoglobulins.
    J. Arnold, M.R. Wormald, R.B. Sim, P.M. Rudd and R.A. Dwek (2007) Ann. Rev. Immunol., 25, p.21-50.
     
  125. Glycobiology - discovery, diagnosis and drugs.
    T.M. Block, A.S. Mehta, P.M. Rudd, M.R. Wormald, D.R. Burton, I.A. Wilson, S.M. Petrescu, F.M. Platt, N. Zitzmann, T.D. Butters and R.A. Dwek (2007) in "Glycobiology", p.8-11, ed. C. Sansom and O. Markman, pub. Scion Publishing Ltd.
     
  126. Crystallographic, thermodynamic, and molecular modelling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin.
    N.E. Ziolkowska, S.R. Shenoy, B.R. O'Keefe, J.B. McMahon, K.E. Palmer, R.A. Dwek, M.R. Wormald and A. Wlodawer (2007) Proteins, 67, p.661-670.
     
  127. Synthesis of and NMR studies on the four diastereomeric 1-deoxy-D-ketohexoses.
    N.A. Jones, S.F. Jenkinson, R. Soengas, M. Fanefjord, M.R. Wormald, R.A. Dwek, G.P. Kiran, R. Devendar, G. Takata, K. Morimoto, K. Izumori and G.W.J. Fleet (2007) Tetrahedron Assymetry, 18, p.774-786.
     
  128. Efficient synthesis from D-lyxonolactone of 2-acetamido-1,4-imino-1,2,4-trideoxy-L-arabinitol LABNAc, a potent pyrrolidine inhibitor of hexosaminidases.
    J.S.S. Rountree, T.D. Butters, M.R. Wormald, R.A. Dwek, N. Asano, K. Ikeda, E.L. Evinson, R.J. Nash and G.W.J. Fleet (2007) Tetrahedron Letters, 48, p.4287-4291.
     
  129. Synthesis 2-C-branched derivatives of D-mannose: 2-C-aminomethyl-D-mannose binds to the human C-type lectin DC-SIGN with affinity greater than an order of magnitude compared to that of D-mannose.
    D.A. Mitchell, N.A. Jones, S.J. Hunter, J.M.D. Cook, S.F. Jenkinson, M.R. Wormald, R.A. Dwek and G.W.J. Fleet (2007) Tetrahedron Assymetry, 18, p.1502-1510.
     
Patents
The use of a reagent array analysis method (RAAM) to determine the monosaccharide sequence of oligosaccharides. R.A. Dwek, C.J. Edge, R.B. Parekh, T.W. Rademacher and M.R. Wormald.
Invited Research Lectures
NMR studies of liquid-liquid interfaces using magnetic susceptibility changes. Lecture given at “NMR in Colloid and Interface Science”, BRSG and the CSIG meeting, Bristol, UK, 1988.
NMR studies of the channel forming fragment of colicin E1. Lecture given at Department of Biological Sciences, Purdue University, USA, 1989.
NMR studies of bacterial ferric uptake regulatory protein. Lecture given at “Metals in Medicine and Biology”, IBDG meeting, Essex, UK, 1989.
Structural Glycobiology. Lecture given at “NMR in Biochemistry”, Dutch Biochemical Society Meeting, Nijmegen, Netherlands, 1991.
NMR in Glycobiology. Lecture given at “Recent Developments in NMR Spectroscopy”, Swedish NMR Centre Symposium, Stockholm, Sweden, 1994.
NMR studies of oligosaccharide-protein interactions. Lecture given at “XVIth ICMRBS”, Veldhoven, Netherlands, 1994.
Use of NMR and computer modelling in understanding the functional roles of glycosylation. Lecture given at “XVIIth National NMR Symposium”, VTT/Finnish Chemical Society, Helsinki, Finland, 1995.
Physical techniques for oligosaccharide analysis: MS and NMR.
Structure and dynamics of oligomannose oligosaccharides.		 Lectures given at “Perspectives in Glycobiology”, Romanian Academy/Royal Society, Bucharest, Romania, 1997.
Structure and recognition of oligosaccharides.
Concluding remarks and summary.		 Lectures given at “The structural approach to the immune system - communication and folding”, Goteborg, Sweden, 1998.
Structure and flexibility of oligosaccharides. Lecture given at “1st International Meeting of the Romanian Society of Biochemistry and Molecular Biology”, Bucharest, Romania, 1998.
Characterising the conformations of oligosaccharides. Lecture given at Department of Molecular Biology, Scripps Institute, La Jolla, USA, 1999.
Structure and dynamics in Glycobiology by NMR. Lecture given at “Minisymposium on Structural Glycobiology”,
Goeteborg, Sweden, 2000.
The effects of glycosylation on glycopeptide and glycoprotein conformation and dynamics. Lecture given at “2nd International Meeting of the Romanian Society of Biochemistry and Molecular Biology”,
Cluj-Napoca, Romania, 2001.
Combined use of NMR, crystallography and molecular modelling in studying glycan structures. Lecture given at “Drug Discovery by Design”,
Boston, USA, 2001.
Glycan structure and protein folding. Lecture given at the School of Biosciences,
Birmingham University, UK, 2002.
The complementary use of NMR, crystallography and molecular modelling in determining glycan structures. Lecture given at “Inaugural Biophysical Chemistry Seminar Series”,
PTCL, Oxford University, UK, 2002.
HIV - recognition of the gp120 glycoprotein. Lecture given at the Institute of Biochemistry,
Romanian Academy, Bucharest, Romania, 2003.
Training Course/General Interest Lectures
NMR studies of oligosaccharides and glycoproteins. Lecture and workshop given at “EMBO course on glycoprotein analysis”, Oxford, UK, 1992.
Structure and conformation of protein-associated carbohydrates. Lecture given at “Glycobiology - a new frontier in biochemistry”, Continuing Professional Develpoment Centre, Oxford, UK, 1993.
Structure and conformation of oligosaccharides.
Physical methods for the analysis of oligosaccharides; NMR and Mass Spectrometry.
Fast sequencing by the Reagent Array Analysis Method.		 Lectures and workshop given at “Glycoprotein analysis: advanced approaches, techniques and automated methods”, Bialystock University Medical School, Bialystock, Poland, 1993.
NMR analysis of oligosaccharides. Lecture given at “EMBO practical course on oligosaccharide analysis”, Oxford, UK, 1994.
Introduction to NMR spectroscopy. Lecture given at “GLIBS course in structural glycobiology”, Goeteborg, Sweden, 2000.
Glycobiology and the immune system: How to recognise HIV. Lecture given to the Halley Society, St. Paul's School, London, UK, 2003.
Lecture given at St. Paul's Girls School, London, UK, 2004.
Books
Principles and Problems in Physical Chemistry for Biochemists,
3rd edition.		 N.C. Price, R.A. Dwek, R.G. Ratcliffe and M.R. Wormald
Published by Oxford University Press, ISBN 0198792816 (2001).