Post-Doctoral Position in Synaptic Structural and Functional Plasticity In Memory and Learning:

We are seeking to appoint a post-doctoral researcher to undertake the study of the role of RNA localisation and translational regulation in synaptic function and plasticity. We are using the genetically tractable fruit fly, Drosophila melanogaster, as a model system. The larval neuromuscular junction is a readily accessible glutamatergic synapse and is subject to functional and structural change in response to activity.

The aim of the project will be to elucidate the role of RNA-binding proteins. The project will involve interacting with the MICRON-Oxford imaging Unit and employ a custom-made fast live multi-dimensional imaging system combining electrophysiology with adaptive optics and super-resolution. The selected candidate will follow the dynamics of synaptic RNA and associated factors at high spatial and temporal resolution and in response to activity, using various genetic backgrounds.

A recently hired post-doctoral physicist is currently building the imaging system. You will work in close collaboration to implement an electrophysiological set up, and optimise it for the experimental system of choice. You will be responsible for carrying the highly skilled technical work and designing and executing experiments. You will also have the responsibility of adequately communicating the progress of the work to your supervisor and the rest of the team. You will also be responsible for the practical training of other member of staff and students. You will participate actively in the writing of publications.

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